23andMe Research Innovation Collaborations and Replications Program

Overview

At 23andMe, we are dedicated to not only providing direct-to-consumer genetic testing, but also to advancing biomedical science through genetic research.

The 23andMe Research Innovation Collaborations Program pairs up academic researchers with 23andMe scientists to perform analyses. Through this program, academic researchers can access de-identified, aggregated data from the 23andMe Research Cohort.

The 23andMe Replications Program allows for academics to request for the 23andMe Research team to evaluate if a genotype-phenotype association found in a previous study eplicates in the 23andMe database.

 

Program Update

We are not reviewing applications for our Research Innovation Collaborations or Replications programs at this time. We will keep this page up to date with new information about future application cycles as it becomes available. If you would like to be notified of our next review cycle, please complete the following form with your name, email address, institution, and an optional proposal summary.

 

Who can apply for the Research Innovation Collaborations or Replications Programs?

  • Institutions, whether domestic or foreign, public or private, are eligible to apply provided the research is for non-commercial purposes
  • Researchers at any career stage, including groups of researchers at the same institution will also be considered
  • If multiple institutions are collaborating on a research project, only one application should be submitted on behalf of the consortium

 

Research Innovation Collaborations

The 23andMe Research Innovation Collaborations Program pairs up academic researchers with 23andMe scientists to power genetic discoveries, develop new analysis tools, and improve our interpretation of genetic data.

How do I apply for the Research Innovation Collaborations Program?

Your application will include the following information:

  • A research proposal summary (no more than 500 words)
  • A description of the proposed research project (no more than 2,000 words)
  • A description of unique datasets or analytic tools your research group will provide and any relevant IRB materials (a total of no more than 1,000 words)
  • A list of co-investigators, collaborators, and other personnel
  • An NIH-style biosketch or CV for the principal investigator

 

Replications Program

The 23andMe Replications Program offers for academics to test if their associations replicate in the 23andMe Research Cohort.

How do I apply for the Replications Program?

If you have performed a GWAS and would like a 23andMe scientist to test if your significant associations replicate in the 23andMe Research Cohort, please indicate that you are submitting a request for replication in your proposal. 23andMe will evaluate requests for feasibility on a rolling basis and reach out with next steps once your request has been approved.

Please consider the following when submitting a replication request:

  • 23andMe will perform a look-up of index SNPs that reached genome-wide significance in your dataset in an identical or similar phenotype in the 23andMe Research Cohort.
  • 23andMe will only share summary statistics for your index SNPs. If you would like to receive full GWAS summary statistics, please apply to the Research Innovation Collaborations program.
  • 23andMe does not accept more than one replication submission per quarter. This applies to universities, consortiums, etc.
  • 23andMe will NOT accept modifications after submission. Kindly ensure that you possess a thoroughly developed concept prior to submitting a formal request.

 

FAQs

 

How will applications to the Research Innovation Collaborations and Replications Program be evaluated?

Applications will be evaluated based on scientific quality, and innovativeness, expertise of the investigators, alignment with 23andMe company objectives, and quality and value of any complementary datasets/methodologies.

Are there any additional requirements I should be aware of?

  • Chosen collaborators will have 3 months to complete contracting with 23andMe, to ensure the resources required to support their proposal are available
  • De-identified 23andMe data will be shared in aggregate and cannot be distributed, shared, or sold to third parties
  • Collaborators will receive non-exclusive access to the data
  • Collaborators must agree to publish results in an open-access scientific journals (or open-access articles) and according to 23andMe’s publication best practices.
  • Collaborators may not file for intellectual property rights covering the results of this collaborative research
  • Collaborators must enter into a Data Transfer Agreement with 23andMe

What data can be found in the 23andMe Research Cohort?

23andMe has over 15 million customers, over 80% of whom have consented to allow their aggregate, de-identified data to be used for research. This includes phenotypic data gathered through surveys and web-based assessments. Learn more about the types of phenotype data we collect here.

How diverse is the 23andMe cohort of Research Participants?

23andMe has enrolled large research cohorts representing diverse populations who have been genotyped and phenotyped, and have consented to participate in research. We welcome collaborators who contribute complementary datasets or methodological expertise to leverage these data and enable genetic research and discovery that is equitable for all.

 

Collaboration Outcomes and Impact

Over the years, we have participated in dozens of collaborations with academic institutions on a wide variety of topics.

Our research team has published or collaborated on over 200 scientific papers. For a complete list, visit our Publications page.

 

How does 23andMe protect customer privacy?

Protecting the privacy of our research participants is of critical importance to 23andMe. Data sharing is structured to provide the same robust privacy protections that 23andMe research participants have as part of their normal participation in 23andMe Research. Only data from 23andMe customers who have accepted 23andMe’s IRB-approved consent document will be incorporated into any analysis. Only de-identified, aggregate data will be shared – no individual level data will be shared. All applicants should take this policy into consideration when designing the research approach.

Any data sharing will take place in accordance with the terms of the 23andMe Data Transfer Agreement between a collaborator, the collaborator’s institution, and 23andMe. Any actions taken by our collaborators that threaten the privacy of 23andMe research participants are grounds for termination of the collaboration and to other remedies described in such agreement.